WEF: How AI is Fundamentally Changing the Operational Needs of Startups

Discover how AI is transforming startup operations, reshaping business models, and redefining what early-stage companies need to scale successfully.

Marc Penzel
Marc Penzel
FOUNDER & PRESIDENT
On April 9, 2025

Image credit: World Economic Forum/Dell/Unsplash

At Startup Genome, we are dedicated to clarifying the opportunities and challenges that AI brings to startups and regions as the digital economy continues to evolve at a rapid pace. In a recent article for World Economic Forum, Startup Genome President & Founder, Marc Penzel, spoke in depth to founders of some of the fastest-growing AI-native startups — including Coframe and Didero — revealing first-hand insights into how AI is fundamentally reshaping the landscape of entrepreneurship, giving rise to AI-native startups.

How AI is fundamentally changing the operational needs of startups

From Abu Dhabi to Zurich, artificial intelligence (AI) is transforming industries and redefining how new businesses are created. AI-native startups are companies whose core products are built from the ground up on AI technologies. By doing this, they accelerate the time to market and revenue, reduce the need for scaling teams and pose questions to venture capitalists and government leaders alike.
 

In-depth conversations with the founders of some of the fastest-growing AI-native startups — including Coframe and Didero — reveal first-hand insights into how AI is actively reshaping the global startup ecosystem.
 

Four key themes stand out:
 

1. From workforce to workflow: AI is impacting startup scalability
Traditionally, scaling a startup meant hiring more employees, but AI is rewriting this narrative. AI-native startups achieve product-market fit with smaller teams and higher levels of automation. As Kevin Terrell, founder of BirchAI, now a Sagility company, explains: “We’ve seen incredible efficiencies with how we run our business. We’ve highly productized our solution. Even with Fortune 500 healthcare clients, the workload per engineer is minimal.”
 

This points to a broader economic shift: the classic correlation between startup success and job creation is weakening. Policy-makers need to rethink how they define and measure entrepreneurial impact and approach job creation from a different perspective.

 

Visit World Economic Forum to read the full article.

Stay up to date

Stay up to date with Startup Genome by subscribing to our newsletter and following us on LinkedIn for the latest insights, reports, and ecosystem trends.

Contact us

This site uses cookies from Google to deliver its services and to analyze traffic. Your IP address and user-agent are shared with Google along with performance and security metrics to ensure quality of service, generate usage statistics, and to detect and address abuse.